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Collectively, the strong neuroanatomical enrichment of PDE1B and PDE10A within schizophrenia-relevant neuronal circuits, coupled with supportive preclinical evidence for PDE1B and more advanced clinical pharmacology for PDE10A, provides a compelling rationale to prioritize these isoforms over PDE2, PDE4, PDE8, and PDE9 in schizophrenia drug development

Research published in the Annals of Pharmacotherapy confirms that none of the 25 topically applied products examined listed semaglutide, tirzepatide, or another FDA-approved GLP-1 agonist as an active ingredient

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On concentrations, published research clusters around 1% for finished products

Neurology 2001

Patients undergoing pre-employment drug screening, athletic drug testing, or legal drug testing should not be concerned about semaglutide detection