If it does not, consider lowering or discontinuing the dose
If mental health medicines are part of your history, our resource on Wellbutrin Weight Loss explains one medication-related example, while Antidepressants That Cause Weight Loss covers a broader comparison
not FDA-approved as of January 2025 Best Phase 2 result / 24.2% mean body weight loss at 48 weeks (12 mg dose, N=338 trial) Extended estimate / 28.7% mean weight loss projected at 68 weeks in Phase 2 modeling Dosing schedule / Once weekly subcutaneous injection (doses 1 mg through 12 mg tested) Comparator benchmark / Semaglutide 2.4 mg: 14.9% at 68 weeks (STEP-1, N=1,961) Comparator benchmark / Tirzepatide 15 mg: 20.9% at 72 weeks (SURMOUNT-1, N=2,539) Primary side effects / Nausea, vomiting, diarrhea, constipation (dose-dependent) Phase 3 status / Phase 3 program (TRIUMPH trials) enrolling as of 2024 Manufacturer / Eli Lilly and Company What Is Retatrutide
Per WellMedr's brand materials, most patients are described as experiencing reduced appetite within the first week, with visible changes described as occurring within 30 to 60 days
All patients were 45 years or older, with an initial BMI of 27 kg/m2 or greater and established CV disease (prior myocardial infarction, prior stroke, or peripheral arterial disease)
PlexusDx Semaglutide: Personalized Dosing and Genetic Insights PlexusDx offers compounded semaglutide injections from licensed 503A pharmacies, at $189/mo month-to-month, or from $149/mo on the 6-month plan across all dose strengths