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Gastrointestinal symptoms (nausea, diarrhea, constipation, abdominal pain) are most common, typically occurring during dose escalation and often improving with continued use
In obese diabetic mice with elevated inflammatory signaling in liver, administration of an FGF21 analog reduces hepatic activation of NF-B and JNK1/2, inhibiting TNF expression and consequent macrophage recruitment (152)
This dual benefitimproving blood sugar and aiding in weight lossmakes tirzepatide an attractive option for people with type 2 diabetes, many of whom struggle with both issues
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In these animal studies, there have been some concerning findings, including potential harm to the developing fetus
