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In a large study in more than 5000 participants with type 2 diabetes, it was shown that poor glycaemic control was associated with anhedonia but not depression or anxiety [119], suggesting that anhedonia may be more important than general depression scores

10.1038/s41467-022-35294-2 291 YangY.RoweD.McCannH.ShepherdC

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The augmented insulin secretion may account for glucose-lowering by metformin in the current study, but the underlying mechanisms remain unclear

The two must not be conflated

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