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A subsequent pilot study (n=12) comparing oral liposomal glutathione (500 mg twice daily for 2 weeks) found increases in GSH levels in whole blood, erythrocytes, and plasma, along with reductions in 8-isoprostane (a marker of oxidative stress) (Buonocore et al., Oxid Med Cell Longev, 2016) [16]
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Additionally, chitosan microspheres and photocrosslinked GelMA hydrogels encapsulating sinomenium (SIN) have been shown to regulate autophagy and improve OA progression by targeting chondrocytes ( Mitochondria-regulating hydrogels extend the protective role by specifically targeting mitochondrial dysfunction, which is intricately linked to OA pathology (Lpez De Figueroa et al., 2015)
Garvey WT, et al
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