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FASEB J (2015) 29(3):796806

You can read the full NHS guidelines on obesity management

The paradox of Prader-Willi syndrome: a genetic model of starvation

Due to the ongoing need for a treatment for Wolfram syndrome, the authors have aimed to evaluate the therapeutic potential of glucagon-like peptide 1 receptor (GLP-1R) agonists under WFS1 deficiency with a particular focus on human beta cells and neurons. By comparing the effects of GLP-1R agonists in mice and human preclinical models with Wolfram syndrome, their research provides evidence supporting that GLP-1R agonists on WFS1-deficient human pancreatic beta cells and neurons are beneficial

While specific studies on oral HRT havent been published, the same mechanism applies

The ideal timing varies for each person