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Organ and Tissue Growth (Moderate Evidence Caution Required) LR3 IGF-1 infusion in guinea pigs significantly increased the weight of adrenals, gut, kidneys, and spleen while suppressing endogenous IGF-1 and IGFBP concentrations (Bastian et al., 1993)

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428,429 However, the reported findings are inconsistent, possibly due to selection bias and small study sizes