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The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)
The timing aligns with the period when acetaminophen became ubiquitous in pregnancy and early childhoodaffecting both prenatal brain development and postnatal exposures during critical developmental windows
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Gastrointestinal Effects: Mild nausea, abdominal cramping, bloating, and flatulence may occur, especially during the initial supplementation period
However, human clinical safety data remain extremely limited
Frontiers in Cell and Developmental Biology (PMC8116695) (2021) 5
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