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Mutations in DET1 (D324A/R137A) slightly weakened its interaction with Ube2e2, while triple mutant D324A/R317A/D289A or quadplex mutant D324A/R317A/D289A/H297A completely abolished their interaction
doi:10.1542/peds.113.5.e494
If reconstituted, follow lab SOP for temperature and stability Handling: Use appropriate personal protective equipment
The weight loss effect comes primarily from reduced appetite and slower digestion
Web Links However, sodium selenate supplementation failed to totally eradicate Keshan disease like you would expect if it was caused by selenium deficiency
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