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Among these, JHU395, a prodrug of DON, shows superior cell penetration compared to DON itself

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Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes

In contradistinction to autophagy and apoptosis, cells subjected to ferroptosis manifest specific cytological alterations, namely dysmorphic mitochondria with condensed membrane, diminished/vanished cristae, and ruptured outer membrane ( Figure 1 In the event of ocular diseases, RCD has been observed to be predominantly executed through apoptosis

Vehicle control groups received a continuous infusion of 0.9% sterile saline

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