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A., and Eclache, J
Combination GABA with GAD immunization increased the duration of syngenic -cell survival in diabetic NOD mice from 1 week in control-diabetic mice to 10 weeks with maximal GABA doses (GABA 6 ml/ml in drinking water + 100 mg GAD immunization) ( Finally, in severely diabetic NOD mice, low-dose anti-CD3 (35 mcg) and lesgaberan, a GABA-B receptor agonist (0.08mg/ml in drinking water), rapidly lowered blood glucoses and preserved functional -cells over a 25-week treatment period ( Notably, GABA has shown anti-diabetic actions in diverse T1D rodent models, including NOD mice, multiple low dose STZ mice as well as humanized rodent models such as the NOD/Lt-SCID-IL2rg or NSG mouse ( 2.3 GABA promotes -cell proliferation and survival Loss of -cell mass due to a reduction in -cell proliferation/regeneration and accelerated -cell apoptosis are synergistic processes leading to the clinical manifestations of TID
Magnesium Although magnesium alone will not directly treat high homocysteine levels, magnesium may be able to improve heart health by boosting blood flow and reducing high cholesterol and blood pressure (x)
Their effect sizes or the SMDs are tabulated in Table 2
Both iron and B12 are critical for thyroid hormone production and should be monitored regularly
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