Profits and losses discipline people to learn quickly from and fix their mistakes
Gut (2014).10.1136/gutjnl-2014-307913 196 IchimuraAHasegawaSKasubuchiMKimuraI
Studies conducted in various animal models provide convincing evidence that inflammation originates in the intestine due to the modulation of gut barrier function leading to metabolic endotoxemia ( Figure 1 ), which allows undesirable luminal immunogens, such as LPS, but also bacterial DNA and RNA and to some degree viable bacteria, to cross into the blood and lymphatic system ( Figure 1 Although many studies have reported on the role of microbiota in obesity and T2D, these mainly focused on characterization of microbiota composition and diversity in response to diet, disease and treatment ( Taken together, these studies suggest that gut health, barrier function and the intestinal immune system play an integral role in the development of metabolic disease and may place the intestines at the center and perhaps the beginning of the pathophysiology of obesity and T2D ( Figure 1 )
Supplement manufacturers do not
Its also good to share any concerns or questions
However, its important to understand both what they do and what they dont do