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In the phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), participants receiving higher doses of retatrutide achieved mean weight reductions of up to 17.5% of body weight over 24 weeks, with greater losses reported at 48 weeks

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It copies the action of a natural gut hormone released after meals

GPx4 uses the reducing power of glutathione to convert highly toxic lipid hydroperoxides into harmless, non-toxic lipid alcohols