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The combination group had the most significant response, but all experienced significant reductions in skin luminosity differences between hyperpigmented and normal skin areas.Similarly, Handog et al found oral combination therapy with vitamins A, C, E, and procyanidin effective for treating Filipino women with melasma
Epilepsia 43:5359, X;Pagegroup:String:Publication
PMID 21307838
The included studies varied in design, populations, drug regimens, treatment duration, and body-composition methods
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