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These authors also discovered that metformin enhanced the anti-hepatoma effect of tubulin depolymerization inhibitor epothilone A by enhancing its pro-apoptotic effect and increasing levels of NF-B (94)
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GSK-3 inhibitors GSK-3 regulates multiple critical intracellular signalling pathways and it has been implicated in the pathogenesis of numerous diseases, including cancer [305], myocardial diseases [306], and neurodegenerative diseases [307]
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