Because it activates both, it's often called a "dual agonist." The FDA has described tirzepatide (brand name Zepbound) as the first medication of its kind to activate both of these receptors for weight management, and it was approved for that use in November 2023
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Participants were randomized to receive either semaglutide or placebo in a 2:1 ratio, combined with a low-calorie diet for the first 8 weeks, followed by intensive behavioral therapy for 68 weeks, including 30 counseling visits
FDA proposes broad approach for conducting safety trials for type 2 diabetes medications (2020)
In addition, female patients should be counseled that the medications may make birth control pills less effective. For more information: Joyce M
Rotate injection sites with each dose and seek training from your practice nurse if uncertain about technique