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The population-level cardiovascular benefits were so clear that making them more accessible seemed obvious
Sanders highlighted the stark disparity in global pricing for GLP-1 medications: Americans pay over $1,300 for a 28-day supply of Wegovy while patients pay far less in countries like Denmark ($186), Germany ($137) and the UK ($92)
In a separate analysis also presented at the same conference, Horneff and his colleagues reported that GLP-1 use was also associated with a roughly 50 percent increased risk over five years of several types of tendon ruptures - including those in the pectoralis major (connecting the shoulder to the chest), rotator cuff (stabilizing the shoulder joint) and Achilles (running from the lower leg to the heel)
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One of these applications describes pairing GLP-1 medications with another type of drug that blocks orexin receptors (orexin-1 or orexin-2) in the brain for treating opioid addiction
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