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They interact with receptors across multiple systems, including the pancreas, brain, and gastrointestinal tract, to coordinate the regulation of glucose balance, appetite behavior, and digestive timing

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however, its function in other tissues, especially during erythropoiesis, is poorly understood

Glucagon in disease Hyperglucagonaemia contributes to a variety of diseases Hyperglucagonaemia has been reported in various diseases/conditions including type 2 diabetes, type 1 diabetes, obesity, fatty liver diseases and kidney diseases [22]