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Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat

The Phase 3 TRIUMPH-4 trial (68 weeks) achieved average weight reductions of 28.7% at the 12 mg dose

It doesnt cleanse the body in the way wellness marketing often implies

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In June 2023, Lilly announced that Retatrutide achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight and a mean weight reduction up to 24.2% at 48 weeks during phase II studies

These medications help reduce appetite, improve satiety, and support sustainable weight loss when combined with healthy lifestyle habits