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The STEP trials demonstrated that patients on semaglutide maintained 6572% of their initial weight loss after 68 weeks, far exceeding placebo results
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More serious risks include hypoglycemia (particularly when used with insulin or sulfonylureas), acute kidney injury, pancreatitis, gallbladder disease, and potential thyroid C-cell tumors (based on animal studies)
Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR
In SURMOUNT-1, a 72-week trial, adults on the highest branded tirzepatide dose (15 mg) lost roughly 20%
