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Additional models: cartilage, endocrine, kidney In cartilage/chondrocyte culture models: FOXO4-DRI reduced the number of senescent chondrocytes significantly, while healthy chondrocytes remained intact

Vitamin B12 deficiency has been tied to the genetics of various populations, which can affect the pathways of uptake and metabolism

Numerous preclinical reports have highlighted the ability of curcumin to restore reduced GSH levels and the activities of GSH-related antioxidant enzymes in the myocardium after exposure to cardiotoxic factors, for example, DOX, I/R, diabetes, hyperthyroid conditions, and copper sulfate [184,185,186,187,188]

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