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Frueh linked the issues of Operator Syndrome primarily to traumatic brain injuries (TBIs), which he said, based on anecdotal estimates, affect a whopping 85 percent of special operators from training alone

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Two structural modifications distinguish this analog from the parent tridecapeptide: substitution of Met-4 with norleucine (Nle) and inversion of Phe-7 to the D-enantiomer, both of which are widely documented in the peptide chemistry literature as means of increasing conformational and oxidative stability of the reference standard

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Substance Use & Misuse