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The two systems act on different receptors in different brain regions, which means combining them in research models can reveal synergistic effects that neither pathway produces alone

Improved microcirculation nourishes hair roots

GHK-Cu has been widely studied as having an important place in dermatological research due to its ability to increase skin elasticity, reduce wrinkles and support overall skin regeneration

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Taking these observations further, epidermal-specific (K14-cre mediated) ER null mice were shown to phenocopy global ER nulls, and the ER agonist DPN was shown to directly promote keratinocyte migration in vitro, suggesting a key role for epidermal ER [128]