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Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

Doses above 3 mg per day lack additional evidence of benefit and are not generally recommended

Two men reported serious adverse drug reactions (hepatic cytolysis requiring hospitalization and abdominal pain requiring a visit to the emergency department) (Rochoy et al., 2022)

Folate deficiency in these patients is usually more severe than vitamin B12 deficiency

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