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Finally, the L protein catalyzes the re-oxidation of the lipoyl moiety of the H protein in an NAD + -dependent reaction, generating NADH and a proton (H + )

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Notably, mutations in the GLUT2 gene affect the glucose-lowering efficacy of metformin (Zhou et al., 2016), which may be one of the reasons for individual differences in metformin efficacy

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