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PBS was administered as a control
As noted, the present knowledge is limited, and these are considerations, not strong recommendations
Liraglutide reduces CNS activation in response to visual food cues only after short-term treatment in patients with type 2 diabetes
Acute Pancreatitis Likely Due to Semaglutide [PMID: 39308839] Laboratory literature summary: Acute Pancreatitis Likely Due to Semaglutide
Renal impairment GLP-1 RAs are generally safe in patients with CKD and have demonstrated nephroprotective effects in the FLOW trial, where semaglutide significantly reduced the composite renal endpoint (hospitalization for acute kidney injury, sustained 50% decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or renal death) in patients with type 2 diabetes and CKD [15]
For a deeper look at the comparison framing, see our GLP-1 vs GIP vs glucagon analysis, which argues the GLP-1 receptor itself may not be the most important contributor to weight loss in dual and triple agonists
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