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GLP1 therapies can deliver impressive weight loss (15%), but most people regain weight after stopping treatment (Panel A)
This means that it mimics the hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), both of which naturally regulate appetite and insulin
Increased heart rate: A modest increase in resting heart rate has been observed with GLP-1 receptor agonists and should be monitored
In contrast, Beta-1 receptors are mainly distributed in the heart, and can increase myocardial contractility, self-regulation, and conduction function
In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months
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