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Thyroid tumor: People with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not use tirzepatide due to the potential risks of thyroid tumors
Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE
When to seek medical advice Mild bloating is expected for many patients starting GLP-1 treatment and often settles with time
The gastrointestinal effects of GLP-1 agonists require careful consideration in the context of an already compromised digestive system, and UK product licences include specific cautions regarding use in severe gastrointestinal disease
These effects are seen even outside of diabetes control.[ref] Decreased colon cancer mortality: A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)
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