2024 Available from: [Last accessed on 2024 Oct 24]
2B) [39,40,41]
European Medicines Agency (EMA) (2023) Topiramate / phentermine direct healthcare professional communication: new restrictions to prevent exposure during pregnancy
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Seek medical advice promptly if you experience : Severe or persistent vomiting : This may lead to dehydration and affect blood glucose control, and could indicate gastroparesis (severe delayed gastric emptying) Severe abdominal pain : Particularly if constant, persistent, or radiating to the back, as GLP-1 receptor agonists carry a small risk of pancreatitis Right upper abdominal pain, fever or jaundice : These may indicate gallbladder problems, which can occur with GLP-1 receptor agonists Signs of dehydration : Including dark urine, dizziness, reduced urination, or extreme thirst Inability to tolerate food or fluids : This affects both nutrition and diabetes management Blood in vomit or stools : This requires immediate medical assessment Symptoms of hypoglycaemia : Particularly if taking Victoza alongside sulfonylureas or insulin For urgent concerns, contact NHS 111 or attend your local A&E department if symptoms are severe
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Approximately 36% of the studies reported multiple anthropometric measures