The most significant clinical evidence for retatrutide to date comes from a Phase 2 randomised, double-blind, placebo-controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al.)
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Hot flushes and night sweats, common symptoms of menopause, can lead to frequent night-time awakenings and reduced sleep quality
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The exact mechanisms are complex, but broadly NAD+ injections may counteract NAD+ depletion and support better cellular function, especially in high-demand tissues like the brain and muscles