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Moreover, T4 has a narrow therapeutic window, where both excessive and insufficient doses can result in suboptimal therapeutic outcomes or adverse effects, further complicating its clinical application (70)

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doi:10.1007/s00125-019-05065-8

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The memory subgroup (experimental group: n = 236

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Metformin Limited data from controlled pharmacokinetic studies of metformin in healthy elderly subjects suggest that total plasma clearance of metformin is decreased, the half-life is prolonged, and Cmax is increased, compared to healthy young subjects

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