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Acute acetaminophen intoxication induces direct neurotoxicity in rats manifested as astrogliosis and decreased dopaminergic markers in brain areas associated with locomotor regulation

R., Heston, W

In the study, a single dose of 3,000 mg of glutathione failed to increase glutathione levels in the blood

What exists is a strong pre-clinical foundation in rodents, a biologically plausible rationale for studying similar effects in dogs, and a clinical patient population that presents with the exact disease categories the rodent literature has focused on

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The negative feedback mechanisms stay more balanced because the body is still controlling the process