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Lilly reported in ACHIEVE-1 that orforglipron lowered A1C by an average of 1.3% to 1.6% across doses, and the full results were published in The New England Journal of Medicine via PubMed in 2025

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This can cause an increase in urination

Brain glucose metabolism in an animal model of depression

Think of it as proving you're ready to make lasting changes, not just relying on medication alone