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Concomitant use with central nervous-system depressants (e.g., benzodiazepines, barbiturates, opioids) could enhance sedation or respiratory depression

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Several GLP-1 agonists are part of this program, including: Exenatide: Results from a large, phase 2 trial in 2017 suggested that exenatide may slow Parkinsons progression

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A hypothetical 60 mg dose could overstimulate these pathways rather than enhance therapeutic effects