CRBNDDB1 FP assay Probe displacement from the CRBNDDB1 complex (performed by Reaction Biology) in the presence or absence of ENL (YEATS) was assessed through FP detection
Adipose vs Other NNMT Research Contexts While adipose is the most-developed NNMT-inhibition research application, NNMT biology has been studied in other contexts too: 5-Amino-1MQ as a tool compound has utility across these contexts, but adipose research is currently the deepest and most-established application area
For instance, in glucose-deficient glioblastoma, heightened SLC7A11 expression leads to the generation of ROS and oxidative stress through the consumption of intracellular NADPH during the conversion of imported L-cystine to L-cysteine (58)
EMT, epithelial-mesenchymal transition
It formally characterises DSIP as a still unresolved riddle acknowledging that no specific DSIP receptor has been confirmed, that the existence of DSIP-like endogenous peptides distinct from DSIP itself may account for a substantial proportion of DSIP-like immunoreactivity data, and that the most robust SWS-promoting activity in rodent studies has been demonstrated for synthetic DSIP structural analogues rather than native DSIP itself
doi: 10.1016/j.redox.2015.07.012 30