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Clinical and experimental studies have reported reduced bone mineral density and increased fracture risk in patients with iron overload, suggesting a direct detrimental effect of excess iron on skeletal homeostasis

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10.1161/CIRCRESAHA.119.315886 31 SuterT.MeyerJ

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5001000 mcg once daily, titrated upward gradually across an 812 week course (about ~5 mg per week on average)

Unfortunately, NAD+ levels decline with age, stress, poor diet, and metabolic dysfunction