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Younes A, Jendiroba D, Engel H, Escudier S, Khouri P, Katz R, Hill D, Rodriguez MA, Cabanillas F, Andreeff M

United States (FDA and DSHEA) Not FDA-approved for weight loss or fat-burning claims AOD9604 was previously investigated as a potential obesity treatment, but the FDA has not approved it as a prescription medication (FDA PCAC briefing)

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This decline manifests as: Impaired recovery from exercise and injury Decreased lean body mass Increased adiposity Poor sleep quality, particularly reduced slow-wave sleep Decreased skin elasticity and wound healing Reduced immune function Critically, these two hormonal systems do not operate in isolation