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Follow-up Repeat metabolic markers after 4-12 weeks, with closer review during dose escalation or major appetite changes

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Interestingly, treatment with 1.5 M defactinib showed a statistically significant increase in FAK, paxillin, and dual FAK and paxillin-containing FAs, highlighting a critical difference in targeting the FAT versus kinase domains of FAK (Fig

10.1016/j.molstruc.2013.01.049 37 GaoT