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The evaluation of RPM supplementation over a 3-month period in rams showed positive effects in increasing serum testosterone and scrotal circumference ( Considering the importance of methionine (MET) as a methyl donor in DNA methylation processes, studies have investigated the effects of RPM supplementation in males on epigenetic regulation, as well as on gene and protein expression profiles related to sperm quality and seminal plasma composition
While adequate folate intake appears protective before malignant change occurs, excessive folic acid exposure, particularly in susceptible individuals with reduced DHFR activity, may not always be desirable