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Kholodenko et al

Peptides, as small proteins, are generally rapidly broken down by enzymes (peptidases) in the blood and tissues

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Collect cells by centrifugation at 200 g for 10 min at 4C

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Laboratory investigations using ionizing radiation-induced senescent cells demonstrate that FOXO4-DRI causes p53 nuclear exclusion and mitochondrial targeting, validating the proposed mechanism of selective senescent cell elimination through targeted protein-protein interaction disruption