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A 2025 review in Frontiers describing the research progress in the pathophysiological mechanisms of Type 2 diabetes framed this as an integrated picture

Addition of incretin therapy to metformin in type 2 diabetes

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Glucagon administration also decreases hepatic triacylglycerol synthesis in rats [56] and stimulates hormone-sensitive lipase in human and rat white adipocytes to promote lipolysis and the release of NEFA [57, 58]

(This is quite common in the drug-development and launch process.) In the drugmaker-sponsored early trials, over 50% of participants lost more than 15% of their body weight