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Separate Phase I data for ipamorelin analogue compounds support safety in humans at doses below 300 mcg [6]

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Second, crossing Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice deletes Jnk1 in hepatocytes during embryogenesis, raising the possibility of compensatory gene induction that could interfere with the final outcome

To assess the G/D-CuPs biocompatibility and its ability to support cell growth, we performed in vitro three-dimensional (3D) culture experiments using NIH/3T3 cells as a model