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Tirzepatide and renal outcomes Tirzepatide Tirzepatide is a dual GIP/GLP-1 receptor agonist designed to engage complementary mechanisms and elicit synergistic and more efficacious responses with respect to monoagonists [39]
In addition to their anti-inflammatory effects, these compounds have inhibitory effects on the following pathways: inflammasome (NLRP3), Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, endothelial cell vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinases involved in remodelling and metastasis (MMP 2, MMP 9), and chronic cycloxogenase derived prostaglandins that promote angiogenesis and immunosuppression (182)
doi: 10.1016/j.yexmp.2019.01.014
J of Thorac & Cardiovasc Surg 151(4), 2016
Glutathione injections contain glutamine, cysteine, and glycine, which neutralize free radicals and promote cellular health
Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death
