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Rat doses of 10 mcg/kg translate to roughly 1.6 mcg/kg in humans, which falls within the commonly compounded dose range of 200-500 mcg/day for a 70 kg individual
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Dossat et al., 2023)
Still measurable but less forgiving of error
Biparatopic HER2-targeting agents (e.g., ZW49, JSKN003) induce receptor clustering and robust internalization
They activate some overlapping populations of neurons, but separate neurons, which, I think, is the basis for their additive effect
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