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It doesn't account for individual physiology, comorbidities, or drug interactions
While treatment with the GLP-1 receptor agonist did not impact the average drinks per calendar day or the number of drinking days, it significantly lowered the number of drinks per drinking day as well as weekly alcohol cravings
For people with type 2 diabetes, the STEP-2 trial showed average weight loss of around 9.6% on the 2.4mg dose, roughly 64% of the result in people without diabetes 4
It is generally avoided in people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
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Overall, body weight reduction was greater with high dose combination, compared to high dose semaglutide
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