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Kim et al., 2016
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Tissue perfusion in critical illnesses
Manufacturing capacity, not just efficacy, is now the biggest competitive differentiator
By designing a molecule that favors the GIPR, Tirzepatide can be dosed to achieve full engagement of the GIP pathway's metabolic benefits, while the less potent but still effective GLP-1R agonism provides its complementary effects without reaching the same tolerability ceiling that might limit a selective GLP-1 RA
This adaptation is a normal biological response, not a sign of treatment failure
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