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Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
Since the use of these injections is mainly in an off-label fashion, meaning not approved by the FDA, you should only seek out a medical office that has experience administering this powerful antioxidant to make sure it is administered safely, with a sterile technique, at the proper dosing, and the correct frequency
Taking the injection with a light meal and staying hydrated can help