Preclinical research on GLP-1 and estrogen conjugates demonstrates enhanced autophagy for clearing amyloid and tau aggregates, reduced neuroinflammation, and improved synaptic function
If your rheumatologist is prescribing methotrexate and your endocrinologist or primary care doctor is prescribing a GLP-1 medication, it's good that they communicate with each other and be aware of what the other's prescribing
In catecholamine biosynthesis of brain and adrenal provides reducing equivalents for dopamine -hydroxylase in the conversion of dopamine to nor-epinephrine, and protects the brain against glutamate mediated excitotoxicity by decreasing the available amount of extracellular glutamate.It can interfere with glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors
For most people, the fix is straightforward smaller and lower-fat meals, fewer sulfur-heavy foods, good hydration, and the occasional over-the-counter helper
What plans want to see: Specific dates of participation in a structured program Nutrition counseling sessions (provider visits, dietitian visits) Documented exercise regimen with duration and frequency Weight history with specific dates and values Previous weight-loss medication trials and outcomes App-based program participation (Noom, MyFitnessPal, Weight Watchers, etc.) Behavioral changes attempted with specific calorie reduction targets If your plan requires this documentation and you have not yet completed it, completing and documenting it now is often faster than fighting the denial
Front Endocrinol (Lausanne) 2023;14:1085799