GLP-1 receptor agonists are a class of medications that mimic glucagon-like peptide-1, a hormone the body produces naturally in the gut after eating
Systematic metabolic benefits In circulation, GLP-1 is primarily produced by intestinal L cells and pancreatic cells (its activity remains controversial), stimulated by the digestion of food or bile acids
Nevertheless, phentermine and Ozempic each have their own potential risks, including side effects, drug interactions, and contraindications
20.4% CagriSema Trial REDEFINE 2 (NEJM 2025) Duration 68 weeks Population T2D + BMI 27 (n=1,206) Mean Weight Loss 13.7% CagriSema vs 3.4% placebo
Understanding these options requires clarity on cost, approval timelines, and clinical fit for individual patients
If youre beginning treatment, hitting a plateau, or considering stopping, youll find practical guidance here