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However, issues included the use of toxic cyanide-containing substances, the high cost of resolving agents and catalysts, the challenge of utilizing the other enantiomer from the resolution, numerous reaction steps, low yield, high cost, and high product price
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Beyond its well-established role in glucose control in diabetes mellitus, GLP-1 has increasingly become the target of anti-inflammatory therapies for the management of conditions such as atherosclerosis, nonalcoholic steatohepatitis, nephropathy secondary to diabetes, and neurodegenerative disorders [44]
For many, GLP-1 medications provide the jumpstart needed to break through years of metabolic resistance
& Makled, M
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